Identification of prebiotic-metabolizing Micro-organisms in the Digestive Tract of Mice using Stable Isotope Sampling of Nucleic Acid

The goal of the project is to identify intestinal micro-organisms which are involved in the transformation of prebiotic carbohydrates. Prebiotics are complex carbohydrates which are difficult to digest, which through increasing growth and activities of health-promoting intestinal bacteria, develop positive effects on their host. These include, e.g. the stimulation of the resorption of water and minerals from the instestine, the protection from pathogenic bacteria or the stimulation of the immune system. As a result, prebiotics are of significant economic importance as a therapeutic in intestinal illnesses (e.g. irritable bowel syndrome, Crohn's disease), but also particularly as an additive in so-called "functional foods".

The micro-organisms which are involved in the breakdown of prebiotic carbohydrates will be identified for the first time with the help of the innovative SIP technology (Stable Isotope Sampling of nucleic acids=SIP) using a mammalian model.

Project Partners

Furtwangen University (Project leader)
Universität Ulm, Institut für Mikrobiologie und Biotechnologie
Duration: 2 years, 2013 – 2015, extended until 2016

The project is funded by the Baden-Württemberg Ministry of Science, Research and the Arts through the "Innovative Projekte" funding programme.

Contact

Prof. Dr. rer. nat. Markus Egert
Faculty of Medical and Life Sciences
Vice Dean
Dean of Studies, Molecular and Technical Medicine (MTZ)
Microbiology lecturer at Hochschule für Forstwirtschaft Rottenburg (since WS 2012/13)
Tel: +49 (0)7720 307-4554
Fax: +49 (0)7720 307-4725
Schwenningen Campus, Room N 11.02
Email: ege(at)hs-furtwangen.de